RAF Typhoon fighter aircraft have operated alongside French aircraft in a joint strike targeting an hidden munitions depot in Syrian territory used by the IS group, per a report from the UK Ministry of Defence.
The site, pinpointed through intelligence, was believed to be containing munitions and bombs, the statement said, and was located in mountainous terrain just north of the ancient city of Palmyra in the heart of Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to strike a series of entry passages leading to the site... initial indications indicate the strike was effective," officials stated.
There was no sign of any civilian impact in the strike late on Saturday and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as Daesh - imposed militant control over large swathes of both Syria and Iraq until 2019.
"This operation demonstrates our UK leadership, and resolve to work closely with our partners, to eradicate any re-emergence of Daesh and their dangerous and violent ideologies in the region," UK Defence Secretary the minister said.
RAF aircraft have performed overwatch operations over Syria to "deter any efforts to regroup" of Islamic State following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces involved in this strike for their expertise and their valour," the Defence Secretary commented. "They were part of a great many UK service members stationed over the holidays. This action, to take out terrorist threats who threaten our security, shows how British military are always on standby, throughout the year, ensuring Britain's security within its borders and influential overseas."
In December, the American forces carried out what it described as a "large-scale strike" against Islamic State objectives in Syria, after an ambush killed two American soldiers and a civilian linguist in the Palmyra area.
The United Nations estimates Islamic State still maintains an estimated 5,000 to 7,000 combatants in Syria and Iraq.